Nuclear protein

A nuclear protein is a protein found in the cell nucleus.^[1] Proteins are transported inside the nucleus with they help of the nuclear pore complex, which acts a barrier between cytoplasm and nuclear membrane. Many nuclear proteins contain positively charged amino acids such as Lysine and Arginine which acts as a signal to allow the protein to get transported into the nucleus while maintaining their fold.^{[citation needed]} The import and export of proteins through the nuclear pore complex plays a fundamental role in gene regulation and other biological functions.^[2][3]

Diagram of nuclear uptake of proteins

The Nuclear Protein Database (NPD) is a database of proteins thought or known to be localized to the cell nucleus from over 1300 species of vertebrates.^[4]