Nucleoplasmin

Nucleoplasmin, the first identified molecular chaperone^[1] is a thermostable acidic protein with a pentameric structure. The protein was first isolated from Xenopus species^[2][3][4]

Nucleoplasmin family
Illustration of the structure of nucleoplasmin
Identifiers
Symbol	NPM
InterPro	IPR004301

Functions

The pentameric protein participates in various significant cellular activities like sperm chromatin remodeling, nucleosome assembly, genome stability, ribosome biogenesis, DNA duplication and transcriptional regulation.^[4][5] During the assembly of regular nucleosomal arrays, these nucleoplasmins transfer the DNA to them by binding to the histones. This reaction requires ATP.^[2][6][7][8]

Human proteins

Humans express three members of the nucleoplasmin family:

• Nucleophosmin (NPM1)
• Nucleoplasmin 2 (NPM2)
• Nucleoplasmin 3 (NPM3)