Solute carrier organic anion transporter family member 1A2

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.^[5][6]

SLCO1A2
Identifiers
Aliases	SLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2
External IDs	OMIM: 602883; MGI: 1351865; HomoloGene: 56603; GeneCards: SLCO1A2; OMA:SLCO1A2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.1 Start 21,264,600 bp[1] End 21,419,594 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G2 Start 142,179,953 bp[2] End 142,268,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment corpus callosum Amygdala optic nerve putamen substantia nigra Hypothalamus caudate nucleus hippocampus proper Brodmann area 9 Top expressed in seminal vesicula vestibular membrane of cochlear duct stria vascularis vestibular sensory epithelium salivary gland choroid plexus Epithelium of choroid plexus olfactory epithelium submandibular gland lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process ion transport organic anion transport bile acid and bile salt transport sodium-independent organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6579 108096 Ensembl ENSG00000084453 ENSMUSG00000063975 UniProt P46721 Q91YY5 RefSeq (mRNA) NM_005075 NM_021094 NM_134431 NM_001267707 NM_130861 RefSeq (protein) NP_066580 NP_602307 NP_001254636 NP_570931 Location (UCSC) Chr 12: 21.26 – 21.42 Mb Chr 6: 142.18 – 142.27 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.^[6]

See also

• Solute carrier family