Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.^[5][6] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.^[7] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.^[8]

SLCO1B1
Identifiers
Aliases	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDs	OMIM: 604843; MGI: 1351899; HomoloGene: 74575; GeneCards: SLCO1B1; OMA:SLCO1B1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.1 Start 21,131,194 bp[1] End 21,239,796 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G2|6 72.57 cM Start 141,575,244 bp[2] End 141,632,372 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle buccal mucosa cell pancreatic ductal cell gallbladder renal cortex cervix canal of the cervix mouth haematopoietic system Top expressed in left lobe of liver embryo sexually immature organism medial head of gastrocnemius muscle primary visual cortex proximal tubule jejunum thoracic diaphragm pancreas right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity sodium-independent organic anion transmembrane transporter activity thyroid hormone transmembrane transporter activity bile acid transmembrane transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane membrane Biological process ion transport bile acid and bile salt transport organic anion transport thyroid hormone transport sodium-independent organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10599 28253 Ensembl ENSG00000134538 ENSMUSG00000030236 UniProt Q9Y6L6 Q9JJL3 RefSeq (mRNA) NM_006446 NM_020495 NM_178235 RefSeq (protein) NP_006437 NP_065241 Location (UCSC) Chr 12: 21.13 – 21.24 Mb Chr 6: 141.58 – 141.63 Mb PubMed search [3] [4]
Wikidata
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See also

• Solute carrier family