SLC22A4

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.^[5][6]

SLC22A4
Identifiers
Aliases	SLC22A4, OCTN1, solute carrier family 22 member 4, DFNB60
External IDs	OMIM: 604190; MGI: 1353479; HomoloGene: 81701; GeneCards: SLC22A4; OMA:SLC22A4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 132,294,394 bp[1] End 132,344,190 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 32.07 cM Start 53,873,949 bp[2] End 53,918,916 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of paranasal sinus right uterine tube trabecular bone nasal epithelium blood olfactory zone of nasal mucosa bone marrow epithelium of nasopharynx monocyte Top expressed in right kidney lumbar subsegment of spinal cord proximal tubule fetal liver hematopoietic progenitor cell granulocyte lip skin of external ear human kidney cerebellar cortex jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding PDZ domain binding transmembrane transporter activity transporter activity protein binding carnitine transmembrane transporter activity secondary active organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity ATP binding symporter activity organic anion transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane apical plasma membrane mitochondrion Biological process body fluid secretion sodium ion transport quaternary ammonium group transport ion transport organic cation transport carnitine transport triglyceride metabolic process carnitine metabolic process cation transmembrane transport ion transmembrane transport carnitine transmembrane transport transmembrane transport organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6583 30805 Ensembl ENSG00000197208 ENSMUSG00000020334 UniProt Q9H015 Q9Z306 RefSeq (mRNA) NM_003059 NM_019687 NM_001330304 RefSeq (protein) NP_003050 NP_001317233 NP_062661 Location (UCSC) Chr 5: 132.29 – 132.34 Mb Chr 11: 53.87 – 53.92 Mb PubMed search [3] [4]
Wikidata
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Function

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.^[7] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").^[5]

Interactions

SLC22A4 has been shown to interact with PDZK1.^[8]

See also

• Solute carrier family