Olfactomedin 1

Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene.^[5][6] The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".^[7]

OLFM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XAT
Identifiers
Aliases	OLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDs	OMIM: 605366; MGI: 1860437; HomoloGene: 8612; GeneCards: OLFM1; OMA:OLFM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 135,075,422 bp[1] End 135,121,180 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,083,004 bp[2] End 28,120,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 10 frontal pole primary visual cortex superior frontal gyrus right frontal lobe dorsolateral prefrontal cortex orbitofrontal cortex Brodmann area 46 Brodmann area 23 Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex hippocampus proper primary motor cortex prefrontal cortex piriform cortex anterior amygdaloid area subiculum cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region cell junction axon soma perikaryon axonal growth cone synapse cell projection endoplasmic reticulum extracellular space Biological process multicellular organism development atrioventricular valve formation neuronal signal transduction positive regulation of gene expression regulation of axon extension positive regulation of epithelial to mesenchymal transition negative regulation of gene expression nervous system development cardiac epithelial to mesenchymal transition positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10439 56177 Ensembl ENSG00000130558 ENSMUSG00000026833 UniProt Q99784 O88998 RefSeq (mRNA) NM_058199 NM_001282611 NM_001282612 NM_006334 NM_014279 NM_001038612 NM_001038613 NM_001038614 NM_019498 RefSeq (protein) NP_001269540 NP_001269541 NP_006325 NP_055094 NP_001033701 NP_001033702 NP_001033703 NP_062371 Location (UCSC) Chr 9: 135.08 – 135.12 Mb Chr 2: 28.08 – 28.12 Mb PubMed search [3] [4]
Wikidata
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This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.^[6]

Cancer

OLFM1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[8]