OSI-7904

OSI-7904 is a noncompetitive liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication.^[1]

OSI-7904

Legal status
Legal status	Investigational
Identifiers
IUPAC name (2S)-2-[6-[(3-Methyl-1-oxo-2H-benzo[f]quinazolin-9-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanedioic acid
CAS Number	139987-54-5
PubChem CID	135403832
UNII	ON177ZCE7M
CompTox Dashboard (EPA)	DTXSID70930683
Chemical and physical data
Formula	C27H24N4O6
Molar mass	500.511 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=NC2=C(C3=C(C=CC(=C3)CNC4=CC5=C(C=C4)C(=O)N(C5)[C@@H](CCC(=O)O)C(=O)O)C=C2)C(=O)N1

OSI-7904L is a liposome-encapsulated formulation of OSI-7904. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904.^[1]

Its effect on solid tumors is currently under evaluation.^[2][3][4]