OSU-6162

OSU-6162 (PNU-96391) is a compound which acts as a partial agonist at both dopamine D₂ receptors and 5-HT_2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely related drug pridopidine, and has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies.^{[1][2][3][4][5][6][7][8][9][10][11][12][13][14]} Both enantiomers show similar activity but with different ratios of effects, with the (S) enantiomer (–)-OSU-6162 that is more commonly used in research, having higher binding affinity to D₂ but is a weaker partial agonist at 5-HT_2A, while the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT_2A but lower D₂ affinity.^[15][16]

OSU-6162

Clinical data
ATC code	none
Identifiers
IUPAC name (3S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine
CAS Number	156907-84-5
PubChem CID	9795741
ChemSpider	7971507
UNII	V5SBJBUJW6
ChEMBL	ChEMBL311730
CompTox Dashboard (EPA)	DTXSID40431531
ECHA InfoCard	100.216.320
Chemical and physical data
Formula	C15H23NO2S
Molar mass	281.41 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCN1CCC[C@H](C1)C2=CC(=CC=C2)S(=O)(=O)C
InChI InChI=1S/C15H23NO2S/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3/t14-/m1/s1 Key:GZVBVBMMNFIXGE-CQSZACIVSA-N

See also

• Flumexadol
• LPH-5
• PF-219,061