SLC22A2

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2^[5]) is a protein that in humans is encoded by the SLC22A2 gene.^[6][7]

SLC22A2
Identifiers
Aliases	SLC22A2, OCT2, solute carrier family 22 member 2
External IDs	OMIM: 602608; MGI: 1335072; HomoloGene: 68293; GeneCards: SLC22A2; OMA:SLC22A2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 160,171,061 bp[1] End 160,277,638 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.61 cM Start 12,803,019 bp[2] End 12,847,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule renal medulla human kidney testicle glomerulus metanephric glomerulus buccal mucosa cell oocyte secondary oocyte right coronary artery Top expressed in right kidney proximal tubule human kidney yolk sac proximal convoluted tubule proximal straight tubule respiratory epithelium olfactory epithelium sciatic nerve embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter activity transporter activity neurotransmitter transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transmembrane transporter activity acetylcholine transmembrane transporter activity norepinephrine:sodium symporter activity secondary active organic cation transmembrane transporter activity organic anion transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane extracellular exosome integral component of plasma membrane presynapse Biological process xenobiotic transmembrane transport body fluid secretion quaternary ammonium group transport neurotransmitter biosynthetic process cation transport ion transport dopamine transport neurotransmitter secretion organic cation transport transmembrane transport ammonium transmembrane transport neurotransmitter transport organic anion transport norepinephrine transport acetate ester transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6582 20518 Ensembl ENSG00000112499 ENSMUSG00000040966 UniProt O15244 O70577 RefSeq (mRNA) NM_153191 NM_003058 NM_013667 NM_001355767 RefSeq (protein) NP_003049 NP_038695 NP_001342696 Location (UCSC) Chr 6: 160.17 – 160.28 Mb Chr 17: 12.8 – 12.85 Mb PubMed search [3] [4]
Wikidata
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Poly specific organic cation transporters in the liver, kidney, intestine, and other organs are important for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.^[7]

See also

• Solute carrier family