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Olutasidenib
Chemical compound From Wikipedia, the free encyclopedia
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Olutasidenib, sold under the brand name Rezlidhia, is an anticancer medication used to treat relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation.[1][2] Olutasidenib is an isocitrate dehydrogenase-1 (IDH1) inhibitor.[1] It is taken by mouth.[1]
The most common adverse reactions include nausea, fatigue/malaise, arthralgia, constipation, leukocytosis, dyspnea, fever, rash, mucositis, diarrhea, and transaminitis.[3]
Olutasidenib was approved for medical use in the United States in December 2022,[1][2][3][4][5][6] based on the phase 1 results of a phase 1/2 trial.[7]
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Medical uses
Olutasidenib is indicated for the treatment of adults with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test.[1][2][3]
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Names
Olutasidenib is the international nonproprietary name.[8]
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