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Overall hemostatic potential
Test used to measure blood coagulation From Wikipedia, the free encyclopedia
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The overall hemostatic potential (OHP) test is a global coagulation assay which can be used to measure coagulation.[1][2][3][4] The OHP assay measures total fibrin generation in the presence of thrombin or tissue factor and tissue plasminogen activator (t-PA).[2][1][3][4] It generates a fibrin time curve through the use of optical density measurement.[1] This curve represents the balance between fibrin formation induced by thrombin or tissue factor and fibrinolysis induced by t-PA.[1] The assay provides three parameters: overall coagulation potential (OCP), overall hemostatic potential (OHP), and overall fibrinolytic potential (OFP).[2][1][4] OHP is the main parameter, while OCP and OFP are supplementary parameters to assess coagulation and fibrinolysis.[3] One further parameter, clot lysis time (CLT), can also be determined.[3] The OHP assay measures the integrated effect of procoagulant, anticoagulant, and fibrinolytic factors.[1]
The OHP is a technically simple[1][3] but relatively labor-intensive assay.[2] As of 2010, it had been implemented in several laboratories, but was not available commercially.[3] The assay is novel in terms of its combined evaluation of both fibrin generation and fibrinolysis.[1] The test is potentially useful in the evaluation of hypercoagulability, hypocoagulability, and fibrinolytic abnormalities.[1][2][3] It is able to detect hypercoagulability associated with pregnancy and estrogen/progestogen hormone therapy.[3][4] The test has also been used to study coagulation in feminizing hormone therapy in transgender women.[5] However, more studies are needed to validate the test as a biomarker of thrombosis and other abnormalities of coagulation.[2][3][4]
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History
The original OHP assay was developed in Sweden by Blombäck and colleagues and was first described in 1999.[1][6][7] It used thrombin to trigger coagulation.[1] Since then, a modified version has been developed which can use either thrombin or tissue factor to trigger coagulation.[1][3][8][9]
References
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