Oxaloglycolate reductase (decarboxylating)

In enzymology, oxaloglycolate reductase (decarboxylating) (EC 1.1.1.92) is an enzyme that catalyzes the chemical reaction

D-glyceric acid

+ CO₂ + NAD⁺

 

 

 

H⁺

 

H⁺

 

2-hydroxy-3-oxosuccinic acid

+ NADH

 

oxaloglycolate reductase (decarboxylating)
Identifiers
EC no.	1.1.1.92
CAS no.	37250-28-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The substrates of this enzyme are D-glyceric acid, oxidised nicotinamide adenine dinucleotide (NAD⁺), and carbon dioxide. Its products are 2-hydroxy-3-oxosuccinic acid, reduced NADH, and a proton. The enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glycerate:NAD(P)⁺ oxidoreductase (carboxylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.