Oxytocin/neurophysin i prepropeptide

Oxytocin/neurophysin I prepropeptide is a protein that in humans is encoded by the OXT gene. ^[5]

OXT
Identifiers
Aliases	OXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
External IDs	OMIM: 167050; MGI: 97453; HomoloGene: 55494; GeneCards: OXT; OMA:OXT - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,071,620 bp[1] End 3,072,517 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.24 cM Start 130,418,093 bp[2] End 130,418,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte testicle hypothalamus gonad right lobe of liver secondary oocyte decidua anterior pituitary subcutaneous adipose tissue right adrenal gland Top expressed in paraventricular nucleus of hypothalamus supraoptic nucleus arcuate nucleus tibiofemoral joint nucleus of stria terminalis right ventricle median eminence gastrula neck lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function oxytocin receptor binding hormone activity neurohypophyseal hormone activity neuropeptide hormone activity Cellular component terminal bouton extracellular region cytoplasm secretory granule extracellular space Biological process response to amphetamine regulation of digestive system process ejaculation positive regulation of hindgut contraction female pregnancy positive regulation of penile erection response to steroid hormone signal transduction response to activity regulation of heart rate response to sucrose positive regulation of ossification positive regulation of synapse assembly drinking behavior hyperosmotic salinity response male mating behavior positive regulation of cytosolic calcium ion concentration response to estradiol regulation of sensory perception of pain response to cAMP response to cocaine response to progesterone positive regulation of blood pressure heart development negative regulation of urine volume response to organic cyclic compound negative regulation of gastric acid secretion positive regulation of prostaglandin secretion response to peptide hormone Maternal behavior negative regulation of blood pressure memory positive regulation of norepinephrine secretion social behavior response to glucocorticoid grooming behavior response to prostaglandin E eating behavior response to ether positive regulation of female receptivity sleep maternal aggressive behavior positive regulation of synaptic transmission response to electrical stimulus positive regulation of uterine smooth muscle contraction response to food response to retinoic acid positive regulation of renal sodium excretion regulation of signaling receptor activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5020 18429 Ensembl ENSG00000101405 ENSMUSG00000027301 UniProt P01178 P35454 RefSeq (mRNA) NM_000915 NM_011025 RefSeq (protein) NP_000906 NP_035155 Location (UCSC) Chr 20: 3.07 – 3.07 Mb Chr 2: 130.42 – 130.42 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone that is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013].