P2RX1

P2X purinoceptor 1, also ATP receptor, is a protein that in humans is encoded by the P2RX1 gene.^[5]

P2RX1
Identifiers
Aliases	P2RX1, P2X1, purinergic receptor P2X 1
External IDs	OMIM: 600845; MGI: 1098235; HomoloGene: 1921; GeneCards: P2RX1; OMA:P2RX1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,896,592 bp[1] End 3,916,476 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B4|11 45.09 cM Start 72,889,929 bp[2] End 72,906,026 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries saphenous vein body of pancreas monocyte granulocyte blood right coronary artery bone marrow cells left coronary artery Top expressed in detrusor urinae muscle umbilical cord blood tunica media of zone of aorta granulocyte thymus embryo tibiofemoral joint Ileal epithelium perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding purinergic nucleotide receptor activity ion channel activity cation channel activity ATP binding extracellularly ATP-gated cation channel activity ATP-gated ion channel activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane integral component of nuclear inner membrane integral component of plasma membrane membrane raft neuron projection secretory granule membrane specific granule membrane external side of plasma membrane protein-containing complex glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic active zone membrane Biological process response to ATP regulation of calcium ion transport synaptic transmission, glutamatergic protein heterooligomerization regulation of smooth muscle contraction vasoconstriction ceramide biosynthetic process serotonin secretion by platelet blood coagulation ion transport response to organic substance cation transmembrane transport platelet activation regulation of blood pressure regulation of vasoconstriction positive regulation of ion transport insemination protein homooligomerization activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of vascular associated smooth muscle contraction neuronal action potential signal transduction apoptotic process purinergic nucleotide receptor signaling pathway neutrophil degranulation excitatory postsynaptic potential regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis cation transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5023 18436 Ensembl ENSG00000108405 ENSMUSG00000020787 UniProt P51575 P51576 RefSeq (mRNA) NM_002558 NM_008771 RefSeq (protein) NP_002549 NP_032797 Location (UCSC) Chr 17: 3.9 – 3.92 Mb Chr 11: 72.89 – 72.91 Mb PubMed search [3] [4]
Wikidata
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The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.^[6]

See also

• P2X receptor