P2RY2

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^[5][6]

P2RY2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z8E
Identifiers
Aliases	P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2
External IDs	OMIM: 600041; MGI: 105107; HomoloGene: 1927; GeneCards: P2RY2; OMA:P2RY2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 73,218,281 bp[1] End 73,242,427 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,645,775 bp[2] End 100,662,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle Skeletal muscle tissue of rectus abdominis mucosa of esophagus vastus lateralis muscle biceps brachii Skeletal muscle tissue of biceps brachii deltoid muscle gingival epithelium triceps brachii muscle Top expressed in muscle of thigh extensor digitorum longus muscle corneal stroma plantaris muscle granulocyte soleus muscle interventricular septum skeletal muscle tissue digastric muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane Biological process G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular ion homeostasis positive regulation of mucus secretion signal transduction blood vessel diameter maintenance G protein-coupled receptor signaling pathway cellular response to ATP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5029 18442 Ensembl ENSG00000175591 ENSMUSG00000032860 UniProt P41231 P35383 RefSeq (mRNA) NM_002564 NM_176071 NM_176072 NM_008773 NM_001302346 NM_001302347 RefSeq (protein) NP_002555 NP_788085 NP_788086 NP_001289275 NP_001289276 NP_032799 Location (UCSC) Chr 11: 73.22 – 73.24 Mb Chr 7: 100.65 – 100.66 Mb PubMed search [3] [4]
Wikidata
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The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[7]

See also

• P2Y receptor
• Denufosol, a P2Y₂ agonist