Pappalysin-2

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.^[5][6][7]

PAPPA2
Identifiers
Aliases	PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA
External IDs	MGI: 3051647; HomoloGene: 10661; GeneCards: PAPPA2; OMA:PAPPA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 176,463,171 bp[1] End 176,845,601 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H1 Start 158,539,297 bp[2] End 158,808,060 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua islet of Langerhans cartilage tissue ventricular zone buccal mucosa cell testicle ganglionic eminence human kidney pancreatic ductal cell stromal cell of endometrium Top expressed in calvaria islet of Langerhans lumbar spinal ganglion pituitary gland pontine nuclei trigeminal ganglion dermis lobe of prostate efferent ductule condyle More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity Cellular component extracellular region extracellular exosome intracellular anatomical structure cytosol apical plasma membrane Biological process bone morphogenesis regulation of cell growth proteolysis response to salt stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60676 23850 Ensembl ENSG00000116183 ENSMUSG00000073530 UniProt Q9BXP8 n/a RefSeq (mRNA) NM_020318 NM_021936 NM_001085376 RefSeq (protein) NP_064714 NP_068755 n/a Location (UCSC) Chr 1: 176.46 – 176.85 Mb Chr 1: 158.54 – 158.81 Mb PubMed search [3] [4]
Wikidata
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