PEPITEM

PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) is an endogenous polypeptide composed of the 14 amino acids 28–41 of the 14.3.3.ζδ protein, which in turn is a 245 amino-acid product of the YWHAZ gene. It has the sequence SVTEQGAELSNEER. PEPITEM has antiinflammatory effects by inhibiting trafficking of T cells into inflamed tissues. Levels of PEPITEM in the body decline with age, diabetes or rheumatoid arthritis, and decreased PEPITEM levels correlates with increases in chronic inflammation and numerous resulting health issues. Administration of synthetic PEPITEM has been suggested as a treatment for various conditions where inflammation plays a role.^{[1][2][3][4][5][6][7][8]}

PEPITEM

Identifiers
IUPAC name L-seryl-L-valyl-L-threonyl-L-α-glutamyl-L-glutaminylglycyl-L-alanyl-L-α-glutamyl-L-leucyl-L-seryl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-Arginine
CAS Number	365226-06-8
PubChem CID	505189302
Chemical and physical data
Formula	C61H101N19O28
Molar mass	1548.584 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@H](O)C)CCC(=O)O
InChI InChI=1S/C61H101N19O28/c1-25(2)20-36(55(102)78-38(24-82)57(104)77-37(21-40(64)85)56(103)73-32(11-16-43(89)90)51(98)72-33(12-17-44(91)92)53(100)75-35(60(107)108)8-7-19-67-61(65)66)76-54(101)31(10-15-42(87)88)70-48(95)27(5)69-41(86)22-68-50(97)30(9-14-39(63)84)71-52(99)34(13-18-45(93)94)74-59(106)47(28(6)83)80-58(105)46(26(3)4)79-49(96)29(62)23-81/h25-38,46-47,81-83H,7-24,62H2,1-6H3,(H2,63,84)(H2,64,85)(H,68,97)(H,69,86)(H,70,95)(H,71,99)(H,72,98)(H,73,103)(H,74,106)(H,75,100)(H,76,101)(H,77,104)(H,78,102)(H,79,96)(H,80,105)(H,87,88)(H,89,90)(H,91,92)(H,93,94)(H,107,108)(H4,65,66,67)/t27-,28+,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,46-,47-/m0/s1 Key:FNMDPJXMBAIAGR-WSBPUMMXSA-N