PF-05105679

PF-05105679 is a drug which acts as a potent and selective blocker of the TRPM8 ion channel, which is the main receptor responsible for the sensation of cold. It was developed as a potential analgesic, and blocks the sensation of cold in both animals and human trials. It also lowers core body temperature in small mammals, but does not produce this effect in humans in the normal dosage range.^[1][2][3]

PF-05105679

Identifiers
IUPAC name 3-({[(1R)-1-(4-fluorophenyl)ethyl]-(quinoline-3-carbonyl)amino}methyl)benzoic acid
CAS Number	1398583-31-7
PubChem CID	60195662
DrugBank	DB15450
ChemSpider	57871141
UNII	F2B10OFV7Y
ChEMBL	ChEMBL3577885
CompTox Dashboard (EPA)	DTXSID301336742
Chemical and physical data
Formula	C26H21FN2O3
Molar mass	428.463 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@H](C1=CC=C(C=C1)F)N(CC2=CC(=CC=C2)C(=O)O)C(=O)C3=CC4=CC=CC=C4N=C3
InChI InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1 Key:BXNMZRPTQFVRFA-QGZVFWFLSA-N

See also

• AMG-333
• RQ-00203078