PF-4800567

PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm,^[1][2] as well as showing potential neuroprotective effects.^[3] While this research has shown that circadian rhythm is modulated primarily by the alternate isoform CK1-δ rather than CK1-ε,^[4] both PF-4800567 and the related non-selective CK1-δ/ε inhibitor PF-670462 were found in animal studies to enhance responses to certain drugs of abuse such as methamphetamine and fentanyl, which suggests a role for CK1-ε in negative regulation of sensitivity to stimulant and opioid drugs.^[5][6]

PF-4800567

Identifiers
IUPAC name 3-(3-chloro-phenoxymethyl)-1-(tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
CAS Number	1188296-52-7
PubChem CID	53472153
IUPHAR/BPS	8050
ChemSpider	26325201
UNII	GEE72DRC63
ChEBI	CHEBI:87237
CompTox Dashboard (EPA)	DTXSID20703849
Chemical and physical data
Formula	C17H18ClN5O2
Molar mass	359.81 g·mol−1
3D model (JSmol)	Interactive image
SMILES c4c(Cl)cccc4OCc(c1c3N)nn(c1ncn3)C2CCOCC2
InChI InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) Key:AUMDBEHGJRZSOO-UHFFFAOYSA-N