Phosphatidylinositol transfer protein, alpha

Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene.^[5]

PITPNA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UW5
Identifiers
Aliases	PITPNA, HEL-S-36, PI-TPalpha, PITPN, VIB1A, phosphatidylinositol transfer protein alpha
External IDs	OMIM: 600174; MGI: 99887; HomoloGene: 55958; GeneCards: PITPNA; OMA:PITPNA - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,517,718 bp[1] End 1,562,792 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.92 cM Start 75,478,923 bp[2] End 75,519,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium parotid gland Pons lateral nuclear group of thalamus skin of leg skin of abdomen monocyte minor salivary glands prefrontal cortex mucosa of esophagus Top expressed in retinal pigment epithelium stroma of bone marrow dentate gyrus of hippocampal formation granule cell pontine nuclei superior frontal gyrus medial vestibular nucleus cerebellar cortex granulocyte ileum jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding phosphatidylcholine transporter activity phosphatidylinositol transfer activity phosphatidylcholine binding phosphatidylinositol binding phosphatidylglycerol binding phospholipid transporter activity Cellular component cytoplasm myelin sheath extracellular exosome intracellular anatomical structure cytosol Biological process visual perception lipid metabolism axonogenesis phospholipid transport interleukin-12-mediated signaling pathway transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5306 18738 Ensembl ENSG00000174238 ENSMUSG00000017781 UniProt Q00169 P53810 RefSeq (mRNA) NM_006224 NM_008850 RefSeq (protein) NP_006215 NP_032876 Location (UCSC) Chr 17: 1.52 – 1.56 Mb Chr 11: 75.48 – 75.52 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro (Wirtz, 1991).^[6]