Plakophilin-3

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.^[5][6]

PKP3
Identifiers
Aliases	PKP3, plakophilin 3
External IDs	OMIM: 605561; MGI: 1891830; HomoloGene: 5200; GeneCards: PKP3; OMA:PKP3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 392,614 bp[1] End 404,908 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,658,131 bp[2] End 140,670,423 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of pharynx human penis skin of arm mucosa of transverse colon mucosa of ileum nipple vulva gums Top expressed in lip epidermis hair follicle esophagus skin of external ear corneal stroma skin of abdomen skin of back saccule crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-catenin binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion RNA binding protein binding enzyme binding translation regulator activity cadherin binding Cellular component desmosome nucleus cell-cell junction cornified envelope nucleoplasm plasma membrane cell junction messenger ribonucleoprotein complex cytoplasm Biological process desmosome assembly cell adhesion keratinization cornification regulation of translation positive regulation of gene expression negative regulation of mRNA catabolic process protein localization to plasma membrane cell-cell adhesion cell-cell junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11187 56460 Ensembl ENSG00000184363 ENSMUSG00000054065 UniProt Q9Y446 Q9QY23 RefSeq (mRNA) NM_007183 NM_001303029 NM_001162924 NM_019762 RefSeq (protein) NP_001289958 NP_009114 NP_001156396 NP_062736 Location (UCSC) Chr 11: 0.39 – 0.4 Mb Chr 7: 140.66 – 140.67 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.^[6]

Interactions

PKP3 has been shown to interact with:

• DSC3,^[7]
• DSG1,^[7]
• DSG2^[7] and
• DSG3.^[7]