Myelin P2 protein

Myelin P2 protein also peripheral myelin protein 2, is a protein that in humans is encoded by the PMP2 gene.^[5][6][7] Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin, also present in small amounts in central nervous system (CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport in Schwann cells. Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins (FABPs).

PMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WUT, 3NR3, 4A1H, 4A1Y, 4A8Z, 4BVM, 4D6A, 4D6B
Identifiers
Aliases	PMP2, FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein, CMT1G
External IDs	OMIM: 170715; MGI: 102667; HomoloGene: 20589; GeneCards: PMP2; OMA:PMP2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 81,440,326 bp[1] End 81,447,439 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A1|3 2.54 cM Start 10,244,911 bp[2] End 10,248,989 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb superior vestibular nucleus trigeminal ganglion inferior ganglion of vagus nerve ventral tegmental area subthalamic nucleus external globus pallidus pars reticulata pars compacta internal globus pallidus Top expressed in blastocyst morula spermatocyte neural layer of retina skeletal muscle tissue quadriceps femoris muscle zone of skin testicle esophagus white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fatty acid binding cholesterol binding protein binding lipid binding transporter activity Cellular component cytoplasm myelin sheath extracellular exosome Biological process membrane organization transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5375 18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search [3] [4]
Wikidata
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