DNA polymerase alpha subunit 2

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.^[5][6][7]

POLA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KEB, 4E2I, 4Y97, 5EXR
Identifiers
Aliases	POLA2, DNA polymerase alpha 2, accessory subunit
External IDs	MGI: 99690; HomoloGene: 48121; GeneCards: POLA2; OMA:POLA2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,261,920 bp[1] End 65,305,589 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,990,570 bp[2] End 6,014,230 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo gonad ganglionic eminence mucosa of transverse colon apex of heart bone marrow cells spleen canal of the cervix granulocyte Top expressed in tail of embryo genital tubercle epiblast spermatocyte yolk sac somite pharynx maxillary prominence mandibular prominence thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-directed DNA polymerase activity protein heterodimerization activity molecular function Cellular component alpha DNA polymerase:primase complex nucleus nucleoplasm cytosol Biological process DNA replication DNA biosynthetic process DNA replication initiation telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23649 18969 Ensembl ENSG00000014138 ENSMUSG00000024833 UniProt Q14181 P33611 RefSeq (mRNA) NM_002689 NM_001164057 NM_008893 RefSeq (protein) NP_002680 NP_001157529 NP_032919 Location (UCSC) Chr 11: 65.26 – 65.31 Mb Chr 19: 5.99 – 6.01 Mb PubMed search [3] [4]
Wikidata
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Interactions

POLA2 has been shown to interact with PARP1.^[8]

See also

• DNA Polymerase
• DNA polymerase alpha