DNA polymerase kappa

"POLK" redirects here. For other uses, see Polk.

DNA polymerase kappa is a DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.^[4][5][6]

POLK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T94, 2LSI, 2OH2, 2W7O, 2W7P, 3IN5, 3PZP, 4BA9, 4GK5, 4U6P, 4U7C
Identifiers
Aliases	POLK, DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappa
External IDs	OMIM: 605650; MGI: 1349767; HomoloGene: 32140; GeneCards: POLK; OMA:POLK - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 75,511,756 bp[1] End 75,601,144 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum superficial temporal artery epithelium of colon mucosa of paranasal sinus skin of hip trabecular bone monocyte islet of Langerhans synovial membrane n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity damaged DNA binding DNA-directed DNA polymerase activity DNA binding nucleotidyltransferase activity metal ion binding protein binding Cellular component nucleoplasm nucleus nuclear body site of DNA damage Biological process nucleotide-excision repair, DNA gap filling DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision DNA biosynthetic process nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus cellular response to UV error-prone translesion synthesis error-free translesion synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51426 27015 Ensembl ENSG00000122008 ENSMUSG00000021668 UniProt Q9UBT6 Q9QUG2 RefSeq (mRNA) NM_016218 NM_001345921 NM_001345922 NM_012048 RefSeq (protein) NP_001332850 NP_001332851 NP_057302 NP_057302.1 NP_001334531 NP_001334532 NP_001334533 NP_001334535 NP_036178 Location (UCSC) Chr 5: 75.51 – 75.6 Mb n/a PubMed search [2] [3]
Wikidata
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