PPP3CB

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.^[5][6][7][8]

PPP3CB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OR9, 4ORA, 4ORC
Identifiers
Aliases	PPP3CB, CALNA2, CALNB, CNA2, PP2Bbeta, protein phosphatase 3 catalytic subunit beta
External IDs	OMIM: 114106; MGI: 107163; HomoloGene: 56429; GeneCards: PPP3CB; OMA:PPP3CB - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,436,433 bp[1] End 73,496,024 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,549,432 bp[2] End 20,596,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii middle temporal gyrus vastus lateralis muscle lateral nuclear group of thalamus superior frontal gyrus orbitofrontal cortex glutes Top expressed in subiculum dorsal striatum triceps brachii muscle olfactory tubercle lateral septal nucleus anterior amygdaloid area medial dorsal nucleus temporal muscle nucleus accumbens sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phosphoprotein phosphatase activity protein dimerization activity protein serine/threonine phosphatase activity metal ion binding calmodulin binding protein binding enzyme binding protein phosphatase 2B binding hydrolase activity calmodulin-dependent protein phosphatase activity Cellular component cytosol T-tubule plasma membrane calcineurin complex nucleoplasm Z discdkac cytoplasm glutamatergic synapse Biological process response to cytokine lymphangiogenesis regulation of insulin secretion calcineurin-NFAT signaling cascade memory learning regulation of synaptic plasticity T cell homeostasis positive regulation of transcription, DNA-templated negative regulation of T cell mediated cytotoxicity T cell proliferation Fc-epsilon receptor signaling pathway protein phosphorylation heart development T cell differentiation axon extension regulation of gene expression social behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus locomotion involved in locomotory behavior T cell activation positive regulation of transcription by RNA polymerase II calcium-ion regulated exocytosis signal transduction dephosphorylation Wnt signaling pathway, calcium modulating pathway protein dephosphorylation regulation of synaptic vesicle endocytosis calcineurin-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5532 19056 Ensembl ENSG00000107758 ENSMUSG00000021816 UniProt P16298 P48453 RefSeq (mRNA) NM_001142353 NM_001142354 NM_001289968 NM_001289969 NM_021132 NM_008914 NM_001310426 NM_001310427 RefSeq (protein) NP_001135825 NP_001135826 NP_001276897 NP_001276898 NP_066955 NP_001297355 NP_001297356 NP_032940 Location (UCSC) Chr 10: 73.44 – 73.5 Mb Chr 14: 20.55 – 20.6 Mb PubMed search [3] [4]
Wikidata
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