Protein kinase, AMP-activated, alpha 1

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.^[5][6]

PRKAA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RED, 4RER, 4REW, 5EZV
Identifiers
Aliases	PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
External IDs	OMIM: 602739; MGI: 2145955; HomoloGene: 49590; GeneCards: PRKAA1; OMA:PRKAA1 - orthologs
EC number	2.7.11.26
Gene location (Human) Chr. Chromosome 5 (human)[1] Band n/a Start 40,759,379 bp[1] End 40,798,374 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 5,173,343 bp[2] End 5,211,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sperm rectum gallbladder gastric mucosa stromal cell of endometrium epithelium of colon tibial arteries body of pancreas Descending thoracic aorta Top expressed in granulocyte islet of Langerhans epithelium of small intestine mammillary body white adipose tissue hand ventromedial nucleus medial vestibular nucleus lateral hypothalamus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cAMP-dependent protein kinase activity [acetyl-CoA carboxylase kinase activity] AMP-activated protein kinase activity histone serine kinase activity chromatin binding metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein C-terminus binding protein binding [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] ATP binding tau protein binding Cellular component nucleotide-activated protein kinase complex apical plasma membrane nucleoplasm nucleus cytoplasm cytosol nuclear speck intracellular anatomical structure axon dendrite protein-containing complex soma Biological process cellular response to organonitrogen compound steroid metabolic process cellular response to glucose starvation sterol biosynthetic process lipid biosynthetic process regulation of transcription, DNA-templated response to hypoxia cellular response to ethanol glucose homeostasis positive regulation of skeletal muscle tissue development protein heterooligomerization rhythmic process phosphorylation lipid metabolism regulation of vesicle-mediated transport negative regulation of apoptotic process cholesterol metabolic process Wnt signaling pathway response to activity fatty acid metabolic process transcription, DNA-templated cellular response to prostaglandin E stimulus autophagy protein phosphorylation negative regulation of TOR signaling cold acclimation positive regulation of gene expression response to camptothecin fatty acid biosynthetic process fatty acid homeostasis regulation of circadian rhythm fatty acid oxidation regulation of peptidyl-serine phosphorylation cellular response to nutrient levels positive regulation of cell population proliferation negative regulation of glucosylceramide biosynthetic process glucose metabolic process positive regulation of cholesterol biosynthetic process response to caffeine cholesterol biosynthetic process negative regulation of lipid catabolic process response to gamma radiation macroautophagy response to UV positive regulation of glycolytic process response to hydrogen peroxide cellular response to hypoxia signal transduction cellular response to hydrogen peroxide steroid biosynthetic process regulation of signal transduction by p53 class mediator positive regulation of autophagy CAMKK-AMPK signaling cascade regulation of macroautophagy chromatin organization positive regulation of mitochondrial transcription positive regulation of protein targeting to mitochondrion negative regulation of gene expression cellular response to oxidative stress intracellular signal transduction negative regulation of insulin receptor signaling pathway motor behavior regulation of stress granule assembly neuron cellular homeostasis regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus energy homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5562 105787 Ensembl ENSG00000132356 ENSMUSG00000050697 UniProt Q13131 Q5EG47 RefSeq (mRNA) NM_006251 NM_206907 NM_001013367 NM_001355640 RefSeq (protein) NP_006242 NP_996790 NP_001341957 NP_001341958 NP_001341963 NP_001341964 NP_001341965 NP_001341966 NP_001013385 NP_001342569 Location (UCSC) Chr 5: 40.76 – 40.8 Mb Chr 15: 5.17 – 5.21 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6] A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.^[7]

Interactions

Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.^[8][9]