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PRR23C
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Proline-rich protein 23C is a protein that in humans is encoded by the proline-rich 23C (PRR23C) gene.
Gene
PRR23C Homo sapiens is located on the long arm of chromosome 3, (3q23) on the antisense strand.[1] When pertaining to the mRNA of PRR23C Homo sapiens, it is 2,791 bp in length.[2] PRR23C Homo sapiens has one exon covering the entire length of mRNA (1-2,791 bp).[3] PRR23C Homo sapiens has a clone name of FLJ46210.[4]
Expression
PRR23C Homo sapiens is expressed in the testis.[5] Ottolini et al. (2014) discussed the PRR23 family to which they revealed that through RNA sequencing data, that PRR23A, PRR23B and PRR23C are testis-specific genes.[6] Ottolini et al. (2014) believes that this family may be a crucial part for the male reproductive system given their RNA-seq data findings.[7]
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Protein
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Proline-rich protein 23C Homo sapiens is 262 amino acids long[8] with a calculated molecular weight of 27,674 Da.[9] Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) which is a conserved domain.[10] DUF2476 belongs to pfam10630 which is a part of superfamily c|11241.[11] DUF2476 is a family of proteins that are rich in proline residues and have unknown function.[12] Proline-rich protein 23C is the preferred name but other aliases include proline-rich protein 23A.[13]
Protein composition
Proline is predicted to be the most abundant amino acid in proline-rich protein 23C Homo sapiens.[14] In comparison to the prevalence of amino acids in other human proteins, it is predicted that proline-rich protein 23C Homo sapiens has a higher abundance of proline along with very low abundances of asparagine, threonine, and lysine.[15] Orthologs for this protein are predicted to also have a high abundance of proline.[16]
Isoelectric point
The basal isoelectric point for PRR23C Homo sapiens was 4.48 (pH) according to phoshosite.org.[17]
Sub-cellular localization
Proline-rich protein 23C is predicted to localize to the nucleus for the human protein and its orthologs.[18] There are predicted nuclear localization signals seen in both the human proline-rich protein 23C and its orthologs.[19]
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Homology
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Orthologs
PRR23C Homo sapiens is strictly conserved in mammals.[20] The table below lists mammalian orthologs for PRR23C Homo sapiens .[21]
Paralogs
There were two paralogs found for PRR23C Homo sapiens: PRR23B and PRR23A. Both have similar sequence identities with PRR23B having 86% identity and PRR23A having 85% identity.[26]
References
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