PSB-CB5

PSB-CB5 (CID-85469571) is a compound which acts as an antagonist at the former orphan receptor GPR18, and is the first selective antagonist characterised for this receptor, with an IC₅₀ of 279nM, and good selectivity over related receptors (over 36x selectivity vs CB₁ and GPR55, and 14x vs CB₂.) As all previously known antagonists for GPR18 also antagonise GPR55, it has been difficult to separate the effects of these two receptor targets, so the discovery of a selective GPR18 antagonist is expected to be useful in research into the actions of this receptor.^[1][2][3]

PSB-CB5

Identifiers
IUPAC name (2Z)-2-[(3-[(4-chlorophenyl)methoxy]phenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one
CAS Number	1627710-30-8 Y
PubChem CID	85469571
ChemSpider	34226942
UNII	75Q5Q6F7LA
CompTox Dashboard (EPA)	DTXSID301031964
Chemical and physical data
Formula	C20H17ClN2O2S
Molar mass	384.88 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc4ccc(cc4)COc(c2)cccc2\C=C(\C1=O)/N=C3N1CCCS3
InChI InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12- Key:XJBQRMOGMULGPP-PDGQHHTCSA-N

See also

• CID-16020046
• O-1918