CYTH3

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.^[5][6]

CYTH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KAX
Identifiers
Aliases	CYTH3, ARNO3, GRP1, PSCD3, cytohesin 3, cytohesin-3
External IDs	OMIM: 605081; MGI: 1335107; HomoloGene: 3116; GeneCards: CYTH3; OMA:CYTH3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 6,161,776 bp[1] End 6,272,644 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 82.36 cM Start 143,608,202 bp[2] End 143,696,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell visceral pleura parietal pleura middle temporal gyrus Brodmann area 23 spinal ganglia trigeminal ganglion saphenous vein tendon of biceps brachii tibia Top expressed in superior cervical ganglion right lung carotid body right lung lobe barrel cortex iris left lung ciliary body endothelial cell of lymphatic vessel fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding guanyl-nucleotide exchange factor activity lipid binding Cellular component cytoplasm ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane membrane Golgi membrane cytosol nucleoplasm adherens junction bicellular tight junction cell junction Biological process regulation of ARF protein signal transduction Golgi vesicle transport positive regulation of cell adhesion establishment of epithelial cell polarity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9265 19159 Ensembl ENSG00000008256 ENSMUSG00000018001 UniProt O43739 O08967 RefSeq (mRNA) NM_004227 NM_001163548 NM_011182 RefSeq (protein) NP_004218 NP_001354509 NP_001354510 NP_001354511 NP_001157020 NP_035312 Location (UCSC) Chr 7: 6.16 – 6.27 Mb Chr 5: 143.61 – 143.7 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.^[6]