PTPRO

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.^[5][6][7]

PTPRO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDs	OMIM: 600579; MGI: 1097152; HomoloGene: 21564; GeneCards: PTPRO; OMA:PTPRO - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3|12p13-p12 Start 15,322,257 bp[1] End 15,602,175 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 137,229,317 bp[2] End 137,440,231 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus rectum ganglionic eminence middle temporal gyrus human kidney ventricular zone nucleus accumbens prefrontal cortex mucosa of transverse colon Top expressed in renal corpuscle arcuate nucleus median eminence olfactory bulb barrel cortex ventromedial nucleus piriform cortex mammillary body dorsomedial hypothalamic nucleus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity protein homodimerization activity phosphatase activity Wnt-protein binding protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity Cellular component integral component of membrane lateral plasma membrane membrane growth cone plasma membrane dendritic spine integral component of plasma membrane axon apical plasma membrane neuron projection extracellular exosome lamellipodium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane Biological process negative regulation of cell-substrate adhesion negative regulation of neuron projection development monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance regulation of glomerular filtration slit diaphragm assembly protein dephosphorylation glomerulus development axon guidance cell morphogenesis glomerular visceral epithelial cell differentiation peptidyl-tyrosine dephosphorylation negative regulation of glomerular filtration negative regulation of canonical Wnt signaling pathway lamellipodium assembly dephosphorylation regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5800 19277 Ensembl ENSG00000151490 ENSMUSG00000030223 UniProt Q16827 E9Q612 RefSeq (mRNA) NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671 NM_001164401 NM_001164402 NM_001164403 NM_011216 RefSeq (protein) NP_002839 NP_109592 NP_109593 NP_109594 NP_109595 NP_109596 NP_001157873 NP_001157874 NP_001157875 NP_035346 Location (UCSC) Chr 12: 15.32 – 15.6 Mb Chr 6: 137.23 – 137.44 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.^[7]