PVC superphylum

The PVC is an invalid (but not disproven as a clade) superphylum of bacteria named after its three important members, Planctomycetota, Verrucomicrobiota, and Chlamydiota.^[2][3] Cavalier-Smith postulated that the PVC bacteria probably lost or reduced their peptidoglycan cell wall twice.^[4] It has been hypothesised that a member of the PVC clade might have been the host cell in the endosymbiotic event that gave rise to the first proto-eukaryotic cell.^[5][6]

PVC
Chlamydia trachomatis
Scientific classification (not accepted by Code)
Domain:	Bacteria
Kingdom:	Pseudomonadati
Superphylum:	PVC
Phyla
Chlamydiota Kiritimatiellota Lentisphaerota Planctomycetota Verrucomicrobiota "Ca. Hydrogenedentes" "Ca. Aureabacteria" "Ca. Omnitrophica"
Synonyms
Planctobacteria Cavalier-Smith, 1987[1]

Cavalier-Smith calls the same group Planctobacteria and considers it a phylum. However, this is not followed by the larger scientific community.^[7] In the Cavalier-Smith bacterial megaclassification, it is within the bacterial Gracilicutes infra-kingdom and comprises the phyla Chlamydiota, Lentisphaerota, Planctomycetota, Verrucomicrobiota.^[4][8]

PVC superphylum[9][10][2][11]

PVC Aureabacteria Planctomycetota Omnitrophica Chlamydiota Kiritimatiellota Lentisphaerota Verrucomicrobiota

Molecular signatures

Planctomycetota, Verrucomicrobiota, and Chlamydiota in the traditional molecular phylogeny view are considered as phyla and also cluster together in the PVC superphylum, along with the candidate phyla Omnitrophica^[12] (previously OP3) and the Poribacteria.^[13] An important molecular marker in the form of a conserved signature protein has been found to be consistently shared by PVC members, with the exception of Poribacteria. The conserved signature protein may be a marker that represents a synapomorphic quality and a means to distinguish this bacterial group. In 2014, studies have characterized this protein and it has been attributed to play an important housekeeping function in DNA/RNA binding.^[14] This observation not only provides a means to demarcate the PVC superphylum, but it supports strongly supports an evolutionary relationship shared by this clade that is distinct from other bacteria.^[15][16]

Conserved signature indels (CSIs) have also been found specific for the Planctomycetota, Verrucomicrobiota, and Chlamydiota that distinguish each respective phylum from one another, and from other bacteria.^[15][17] A three-amino-acid insert in the RNA polymerase protein RpoB has been found that is shared by all sequenced Verrucomicrobia, Chlamydiae, and Lentisphaerae species. The CSI is absent from neighbouring Planctomycetes' and Poribacteria, suggesting common ancestry among the groups for which the CSI is specific.^[15]

Additional lines of evidence for the existence of this clade have been found.^[18][19] These include the presence of membrane coat-like proteins, tubulin, sterol synthesis, and the presence of condensed DNA.

Notes