Paeonol

Paeonol is a phenolic compound found in peonies^[2] such as Paeonia suffruticosa (moutan cortex),^[3][4] in Arisaema erubescens,^[5] and in Dioscorea japonica.^[6] It is a chemical compound found in some traditional Chinese medicines.^[7]

Paeonol

Names
Preferred IUPAC name 1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one
Other names 2'-Hydroxy-4'-methoxyacetophenone
Identifiers
CAS Number	552-41-0[1]
3D model (JSmol)	Interactive image
ChemSpider	10621
ECHA InfoCard	100.008.194
PubChem CID	11092
UNII	3R834EPI82 Y
CompTox Dashboard (EPA)	DTXSID1022059
InChI InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 Key: UILPJVPSNHJFIK-UHFFFAOYSA-N InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 Key: UILPJVPSNHJFIK-UHFFFAOYAG
SMILES CC(=O)C1=C(C=C(C=C1)OC)O
Properties
Chemical formula	C9H10O3
Molar mass	166.176 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Biological effects

A number of biological effects of paeonol in vitro or in animal models have been observed. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.^[8] Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.^[9]

Paeonol shows antimutagenic activities.^[3][6] It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia.^[10] Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α.^[11]

Paeonol has weak MAO-A and MAO-B inhibiting effects with IC₅₀ values of 54.6 μM and 42.5 μM respectively.^[12]

Metal complex

Metal complexes of paeonol shows tetrahedral and octahedral coordination geometry in the absence and presence of solvent pyridine respectively.^[13]