Palmitoleoylation

Not to be confused with palmitoylation.

Palmitoleoylation is type of protein lipidation where the monounsaturated fatty acid palmitoleic acid is covalently attached to serine or threonine residues of proteins.^[1][2] Palmitoleoylation appears to play a significant role in trafficking and targeting and function of Wnt proteins.^[3][4][5]

In palmitoleoylation, a palmitoleoyl group (derived from palmitoleic acid, pictured above) is added.

O-Palmitoleoylation of Wnt proteins is catalysed by PORCN. The inverse reaction is done by NOTUM.^[6]