Pantoate 4-dehydrogenase

In enzymology, pantoate 4-dehydrogenase (EC 1.1.1.106) is an enzyme that catalyzes the chemical reaction

(R)-pantoic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

(R)-4-dehydropantoic acid

+ NADH

 

pantoate 4-dehydrogenase
Identifiers
EC no.	1.1.1.106
CAS no.	37250-38-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are (R)-pantoic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (R)-4-dehydropantoic acid, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD⁺ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD⁺ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.