Pentalenolactone F synthase

Pentalenolactone F synthase (EC 1.14.11.36, PEND (gene), PNTD (gene), PTLD (gene)) is an enzyme with systematic name pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

pentalenolactone D + 2 2-oxoglutarate + 2 O₂ ${\displaystyle \rightleftharpoons }$ pentalenolactone F + 2 succinate + 2 CO₂ + H₂O (overall reaction)

(1a) pentalenolactone D + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ pentalenolactone E + succinate + CO₂ + H₂O

(1b) pentalenolactone E + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ pentalenolactone F + succinate + CO₂

Pentalenolactone F synthase
Identifiers
EC no.	1.14.11.36
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pentalenolactone F synthase contains Fe(II), and ascorbate is needed for its action.