Pepsin A

Pepsin A (EC 3.4.23.1, pepsin, lactated pepsin, pepsin fortior, fundus-pepsin, elixir lactate of pepsin, P I, lactated pepsin elixir, P II, pepsin R, pepsin D) is an enzyme.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe¹-Val, Gln⁴-His, Glu¹³-Ala, Ala¹⁴-Leu, Leu¹⁵-Tyr, Tyr¹⁶-Leu, Gly²³-Phe, Phe²⁴-Phe and Phe²⁵-Tyr bonds in the B chain of insulin

Pepsin A
Pepsin + inhibitor (l.blue), Human
Identifiers
EC no.	3.4.23.1
CAS no.	9001-75-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme is a predominant endopeptidase in the gastric juice of vertebrates.

See also

• Pepsin