Peptidyl-glutamate 4-carboxylase

Peptidyl-glutamate 4-carboxylase (EC 4.1.1.90, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H₂O ${\displaystyle \rightleftharpoons }$ peptidyl-glutamate + CO₂ + O₂ + phylloquinone

Peptidyl-glutamate 4-carboxylase
Identifiers
EC no.	4.1.1.90
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme can use various vitamin-K derivatives, including menaquinone.