Perfluorohexyloctane

"Miebo" redirects here. For the fictional Shang dynasty official, see Mei Bo.

Perfluorohexyloctane (branded as Evotears, Miebo,^[a] and Novatears, among others) is a medication used for the treatment of dry eye disease.^[4] It is a semifluorinated alkane.^[4]

Perfluorohexyloctane

Clinical data
Trade names	Evotears Miebo (/ˈmaɪboʊ/ MY-bow) Novatears
Other names	NOV03; 1-(perfluorohexyl)octane
AHFS/Drugs.com	Monograph
MedlinePlus	a623054
License data	US DailyMed: Perfluorohexyloctane
Routes of administration	Eye drops
ATC code	None
Legal status
Legal status	CA: ℞-only[1][2][3] US: ℞-only[4]
Identifiers
IUPAC name 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorotetradecane
CAS Number	133331-77-8
PubChem CID	10477896
DrugBank	DB17823
ChemSpider	8653305
UNII	7VYX4ELWQM
KEGG	D12604
ChEBI	CHEBI:229658
CompTox Dashboard (EPA)	DTXSID20440585
Chemical and physical data
Formula	C14H17F13
Molar mass	432.269 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
InChI InChI=1S/C14H17F13/c1-2-3-4-5-6-7-8-9(15,16)10(17,18)11(19,20)12(21,22)13(23,24)14(25,26)27/h2-8H2,1H3 Key:WRYIIOKOQSICTB-UHFFFAOYSA-N

Perfluorohexyloctane has been available in multiple markets since 2015 under the brand names Evotears and Novatears,^[5] and was additionally approved for medical use in the United States in May 2023 under the brand name Miebo.^[4][6] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[7]

Medical uses

Perfluorohexyloctane is indicated for the treatment of the signs and symptoms of dry eye disease.^[4][8][9]

Availability

Perfluorohexyloctane is sold as an over-the-counter medication under the brand names Evotears and Novatears in multiple countries,^[10] costing around NZ$34.00, A$30, and €30 for a one-month supply.

In the US, perfluorohexyloctane is sold under the brand name Miebo; a prescription is required.

See also

• Medicine portal