Pethidine intermediate A

Pethidine intermediate A is a four-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,^[2] so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use).^[3]

Pethidine intermediate A

Clinical data
Routes of administration	N/A
ATC code	none
Legal status
Legal status	BR: Class A1 (Narcotic drugs)[1] DE: Anlage II (Authorized trade only, not prescriptible) US: Schedule II UN: Narcotic Schedule I
Identifiers
IUPAC name 1-methyl-4-phenylpiperidine-4-carbonitrile
CAS Number	3627-62-1
PubChem CID	62513
ChemSpider	56289
UNII	EL4L2474TY
KEGG	C22687
CompTox Dashboard (EPA)	DTXSID50189814
ECHA InfoCard	100.020.771
Chemical and physical data
Formula	C13H16N2
Molar mass	200.285 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CCC(CC1)(C#N)c2ccccc2
InChI InChI=1S/C13H16N2/c1-15-9-7-13(11-14,8-10-15)12-5-3-2-4-6-12/h2-6H,7-10H2,1H3 Key:ZLFQTZYFXYOGLS-UHFFFAOYSA-N
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See also

• Moramide intermediate
• Methadone intermediate
• Pethidine intermediate B (norpethidine)
• Pethidine intermediate C (pethidinic acid)