Phenaridine

Phenaridine (2,5-dimethylfentanyl) is an opioid analgesic that is an analogue of fentanyl. It was developed in 1972,^[2] and is used for surgical anasthesia.^[3][4]

Phenaridine

Clinical data
ATC code	none
Legal status
Legal status	US: Schedule I[1]
Identifiers
IUPAC name N-[2,5-Dimethyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide
CAS Number	42045-97-6 N
PubChem CID	162056
ChemSpider	142327 Y
UNII	S07S9928YH
CompTox Dashboard (EPA)	DTXSID00962230
Chemical and physical data
Formula	C24H32N2O
Molar mass	364.533 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N(c1ccccc1)C3CC(N(CCc2ccccc2)CC3C)C)CC
InChI InChI=1S/C24H32N2O/c1-4-24(27)26(22-13-9-6-10-14-22)23-17-20(3)25(18-19(23)2)16-15-21-11-7-5-8-12-21/h5-14,19-20,23H,4,15-18H2,1-3H3 Y Key:ODPKHHGQKIYCTJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Phenaridine has similar effects to fentanyl. It is slightly less potent than fentanyl in rats. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Irresponsible use of fentanyl analogues administrated in several times larger doses than recommended, have ended up in a death of hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[5]

See also

• 3-Methylfentanyl
• 4-Fluorofentanyl
• α-Methylfentanyl
• Acetylfentanyl
• Fentanyl tropane
• Furanylfentanyl
• List of fentanyl analogues