PTPRZ1

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.^[5][6][7]

PTPRZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JXF, 3S97, 5AWX
Identifiers
Aliases	PTPRZ1, HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z1
External IDs	OMIM: 176891; MGI: 97816; HomoloGene: 2136; GeneCards: PTPRZ1; OMA:PTPRZ1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.32 Start 121,873,089 bp[1] End 122,062,036 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.1 Start 22,875,501 bp[2] End 23,052,915 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence endothelial cell amygdala Region I of hippocampus proper optic nerve caudate nucleus nucleus accumbens corpus callosum external globus pallidus Top expressed in vestibular membrane of cochlear duct Rostral migratory stream mammillary body median eminence ventromedial nucleus lobe of cerebellum arcuate nucleus cerebellar vermis lateral septal nucleus anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity integrin binding Cellular component integral component of membrane membrane integral component of plasma membrane extracellular region perineuronal net intrinsic component of plasma membrane plasma membrane extracellular matrix synapse Biological process axonogenesis protein dephosphorylation oligodendrocyte differentiation regulation of oligodendrocyte progenitor proliferation central nervous system development hematopoietic progenitor cell differentiation learning or memory peptidyl-tyrosine dephosphorylation dephosphorylation cytokine-mediated signaling pathway regulation of myelination negative regulation of neuron apoptotic process positive regulation of oligodendrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5803 19283 Ensembl ENSG00000106278 ENSMUSG00000068748 UniProt P23471 B9EKR1 RefSeq (mRNA) NM_001206838 NM_001206839 NM_002851 NM_001369395 NM_001369396 NM_001081306 NM_011219 NM_178180 NM_001311064 NM_001361349 RefSeq (protein) NP_001193767 NP_001193768 NP_002842 NP_001074775 NP_001297993 NP_001348278 NP_035349 NP_001389981 NP_001389982 NP_001389983 Location (UCSC) Chr 7: 121.87 – 122.06 Mb Chr 6: 22.88 – 23.05 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[7]

Clinical significance

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.^[7]