Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P₂ 4-Ptase, type II PtdIns-4,5-P₂ 4-Ptase, IpgD, PtdIns-4,5-P₂ 4-phosphatase type I, PtdIns-4,5-P₂ 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Identifiers
EC no.	3.1.3.78
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P₂].