Phosphoenolpyruvate carboxykinase (diphosphate)

Phosphoenolpyruvate carboxykinase (diphosphate) (EC 4.1.1.38) is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming).^[1] This enzyme catalyses the following chemical reaction

diphosphate + oxaloacetate ${\displaystyle \rightleftharpoons }$ phosphate + phosphoenolpyruvate + CO₂

Phosphoenolpyruvate carboxykinase (diphosphate)
Phosphoenolpyruvate carboxykinase (pyrophosphate) homodimer, Actinomyces israelii
Identifiers
EC no.	4.1.1.38
CAS no.	2598306
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme also catalyses the reaction:

phosphoenolpyruvate + GTP + CO₂ ${\displaystyle \rightleftharpoons }$ pyruvate + GDP.

It is transcriptionally upregulated in the liver by glucagon.

See also

• Phosphoenolpyruvate carboxykinase