Phosphonoacetaldehyde reductase (NADH)

Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + NAD⁺ ${\displaystyle \rightleftharpoons }$ phosphonoacetaldehyde + NADH + H⁺

Phosphonoacetaldehyde reductase (NADH)
Identifiers
EC no.	1.1.1.309
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.