Phosphonoacetate hydrolase

In enzymology, a phosphonoacetate hydrolase (EC 3.11.1.2) is an enzyme that catalyzes the chemical reaction

phosphonoacetate + H₂O ${\displaystyle \rightleftharpoons }$ acetate + phosphate

phosphonoacetate hydrolase
Structure of phosphonoacetate hydrolase. PDB entry 1e16. Zinc ions and phosphonoformate are shown in the active site.
Identifiers
EC no.	3.11.1.2
CAS no.	153570-68-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are phosphonoacetate and H₂O, whereas its two products are acetate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is phosphonoacetate phosphonohydrolase. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, zinc.

Structural studies

The structure of this enzyme, with the PDB accession code 1EI6, shows it adopts the alkaline phosphatase fold.