Pimitespib

Pimitespib (trade name Jeselhy) is a drug for the treatment of gastrointestinal stromal tumors.^[1] It was discovered and developed by Taiho Pharmaceutical Co.^[2] The mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90).^[3]

Pimitespib

Clinical data
Trade names	Jeselhy
Other names	TAS 116
Legal status
Legal status	Rx in Japan
Identifiers
CAS Number	1260533-36-5
UNII	PLO044MUDZ
KEGG	D11920
Chemical and physical data
Formula	C25H26N8O
Molar mass	454.538 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N)C1=CC=C(C(=C1)CC)N2N=C(C=3C2=NC=CC3N4C=NC(=C4)C=5C=NN(C5)C)C(C)C

In June 2022, it received approval in Japan for gastrointestinal stromal tumors that have progressed after chemotherapy.^[4]