PreQ1-II riboswitch

PreQ1-II riboswitches form a class of riboswitches that specifically bind pre-queuosine₁ (PreQ₁), a precursor of the modified nucleoside queuosine.^[1] They are found in certain species of Streptococcus and Lactococcus, and were originally identified as a conserved RNA secondary structure called the "COG4708 motif".^[2] All known members of this riboswitch class appear to control members of COG4708 genes. These genes are predicted to encode membrane-bound proteins and have been proposed to be a transporter of preQ₁, or a related metabolite, based on their association with preQ₁-binding riboswitches.^[1] PreQ1-II riboswitches have no apparent similarities in sequence or structure to preQ1-I riboswitches, a previously discovered class of preQ₁-binding riboswitches. PreQ₁ thus joins S-adenosylmethionine as the second metabolite to be found that is the ligand of more than one riboswitch class.

Consensus secondary structure of PreQ₁-II riboswitches. Layout is similar to that used in previously published depictions.^[2][1]

preQ1-II (pre queuosine) riboswitch
Predicted secondary structure and sequence conservation of preQ1-II
Identifiers
Symbol	preQ1-II
Alt. Symbols	COG4708
Rfam	RF01054
Other data
RNA type	Cis-reg; riboswitch
Domain(s)	Bacteria
SO	SO:0005836
PDB structures	PDBe