Pregnenolone succinate

Pregnenolone succinate
Clinical data
Trade names	Panzalone, Formula 405
Other names	Pregnenolone hemisuccinate; Pregn-5-en-3β-ol-20-one 3β-(hydrogen succinate)
Routes of; administration	Topical
Identifiers
	IUPAC name 4-{{#parsoidfragment:1}}(3S,8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid;
CAS Number	4598-67-8;
PubChem CID	10070529;
ChemSpider	8246069;
UNII	6LN4W6JJK6;
KEGG	D05604;
ChEMBL	ChEMBL2105373;
CompTox Dashboard (EPA)	DTXSID40196673 ;
ECHA InfoCard	100.022.728
Chemical and physical data
Formula	C25H36O5
Molar mass	416.558 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCC(=O)O)C)C;
	InChI InChI=1S/C25H36O5/c1-15(26)19-6-7-20-18-5-4-16-14-17(30-23(29)9-8-22(27)28)10-12-24(16,2)21(18)11-13-25(19,20)3/h4,17-21H,5-14H2,1-3H3,(H,27,28)/t17-,18-,19+,20-,21-,24-,25+/m0/s1; Key:OZZAYJQNMKMUSD-DMISRAGPSA-N;

Pregnenolone succinate (USANTooltip United States Adopted Name; brand names Panzalone, Formula 405; also known as pregnenolone hemisuccinate or pregn-5-en-3β-ol-20-one 3β-(hydrogen succinate)) is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and anti-inflammatory drug and has been patented and marketed as a topical medication in the form of a cream for the treatment of allergic, pruritic, and inflammatory dermatitis.^[1]^[2]^[3] It has also been described as a non-hormonal sterol, having neurosteroid activity, and forming a progesterone analogue via dehydrogenation.^[4]

Quick facts Clinical data, Trade names ...

In addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the GABA_A receptor and a positive allosteric modulator of the NMDA receptor similarly to pregnenolone sulfate.^[5]^[6]^[7]^[8]

See also