ProP (transporter)

ProP is a bacterial membrane protein that is a member of the major facilitator superfamily. It functions as an osmosensory and osmoregulatory transporter, responding to changes in osmotic pressure by importing compatible solutes such as proline or glycine betaine;^[1] most substrates for ProP are zwitterions.^[2] The activity of ProP increases with osmotic pressure in cells and proteoliposomes.^[3][4] ProP is a symporter of hydrogen ions and compatible solutes, and is responsive to potassium concentrations.^[2]

Proline/betaine transporter
Identifiers
Organism	Escherichia coli
Symbol	ProP
PDB	1R48
UniProt	P0C0L7
Search for Structures Swiss-model Domains InterPro

Activity of ProP has been associated with the ability of pathogenic E. coli to colonize the urinary tract.^[3]