Procollagen peptidase

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.^[1]

procollagen (type III) N-endopeptidase
Identifiers
Symbol	PCOLN3
Alt. symbols	PRSM1
NCBI gene	5119
HGNC	8740
OMIM	164010
RefSeq	NM_002768
UniProt	Q9HD42
Other data
EC number	3.4.24.14
Locus	Chr. 16 q24.3
Search for Structures Swiss-model Domains InterPro

The enzyme is present in the skin of rats and humans.^[2]